Table 1. Mean pharmacokinetic parameters for metformin hydrochloride and dexamethasone administered via Osseogate.
| Metformin hydrochloride | Dexamethasone | |
|---|---|---|
| Cmax (ng/ml) | 205.77 | 62.116 |
| Tmax (h) | 2 | 4 |
| AUClast (ng/ml·h) | 2874.02 | 1870.21 |
| AUC∞ (ng/ml·h) | 2874.02 | NAa |
| MRT (h) | 15.05 | NAa |
| Half life (h) | 10.43 | NAa |
Cmax: the maximum plasma concentration; Tmax: the time at which the Cmax is achieved; AUClast: area under curve until the end of observation; AUC∞: area under curve from zero to infinity; MRT: mean residence time.
a
These values were unavailable because the plasma concentration of dexamethasone was still rising at the end of observation.