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. 2017 Nov 28;24(1):1818–1830. doi: 10.1080/10717544.2017.1407011

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Tumor-homing characteristics of the Z_PDGFRβ affibody. (A) Tumor uptake of the Z_PDGFRβ affibody. CF750-labeled Z_PDGFRβ affibody was intravenously injected into mice (n = 3) bearing subcutaneous LS174T tumor grafts (arrow indicated), followed by scanning with SPECTRAL Lago and Lago X Imaging Systems at different times (0–4 h) post-injection. (B) Bio-distribution of the Z_PDGFRβ affibody in mice bearing LS174T tumor grafts. Mice (n = 3) injected with CF750-labeled Z_PDGFRβ affibody were sacrificed at 4 h post-injection for optical imaging of organs/tissues. (C) Co-localization of the Z_PDGFRβ affibody with CD31, PDGFRβ, or NG2 in tumor tissues. FAM-labeled Z_PDGFRβ affibody was intravenously injected into mice bearing LS174T tumor grafts. Tumor grafts were removed and sectioned under freezing conditions, followed by staining with antibody against CD31, PDGFRβ, or NG2. The nuclei were visualized by DAPI staining. Original magnification 200×.