Table 1.
Parameter | AUC (h·ng/mL) | Cmax (ng/mL) | Tmax (h) |
---|---|---|---|
Drug | 8.39 ± 4.78 | 4.70 ± 4.46 | 0.60 ± 1.02 |
Commercial soft capsule | 8.79 ± 5.32 | 4.25 ± 2.63 | 0.62 ± 1.01 |
S-SNEDDS | 28.25 ± 24.25* | 10.65 ± 10.41* | 1.05 ± 0.69* |
Each value represents the mean ± SD (n = 8).
The S-SNEDDS was composed of PLAG/SLS/HPMC/BHA/calcium silicate at a weight ratio of 1: 0.25: 0.1: 0.0002: 0.5.
p < .05 compared with drug and commercial soft capsule.