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(A) Expression of OCTN2 (SLC22A5) and ATB0,+ (SLC6A14) in the normal colon cell line (CCD841) and colon cancer cell lines (Caco-2, HCT116, HT29, LS174T); (B) Uptake of coumarin 6 from LC-PLGA NPs with different ligand density (0 to 10%) in colon cells. Data are shown as mean ± SD, n = 3. *, p < .05, **, p < .01, ***, p < .001, compared to uptake in normal colon cells (CCD841).
