. 2017 Sep 25;24(1):1429–1440. doi: 10.1080/10717544.2017.1377315

Table 2.

Effect of doxycycline hydrochloride and DCNP_opt on various behavioral and biochemical parameters.

	Vehicle	Keta (50 mg/kg)	Keta + Olz (5 mg/kg)	Keta + Placebo (50 mg/kg)	Keta + Doxy (25 mg/kg)	Keta + Doxy (50 mg/kg)	Keta + DCNP_opt (25 mg/kg)
Locomotor counts	283.33 ± 9.61	502.66 ± 7.46^*	359.33 ± 10.44^a	490.50 ± 11.55	444.83 ± 19.61	394.16 ± 8.42^a	304.33 ± 23.4^a^,^x^,^q
Stereotyped behaviors	2.50 ± 0.34	27.66 ± 1.14^*	7.83 ± 0.6^a	26.50 ± 0.84	21.16 ± 1.74^b	18.66 ± 1.47^a	11.16 ± 1.49^a^,^x^,^q
Immobility duration (s)	72.5 ± 1.61	149.83 ± 1.88^*	81.83 ± 1.49^a	146.33 ± 1.99	125.16 ± 2.93^a	114.50 ± 3.08^a	81.16 ± 5.16^a^,^x^,^p
SDL (s)	237.66 ± 14.55	76.83 ± 3.98^*	186 ± 2.22^a	74.16 ± 4.01	80.16 ± 4.52	80.50 ± 4.52	90.83 ± 3.17^#
TNF-α (ng/ml)	125.16 ± 3.65	499.66 ± 9.62^*	128.00 ± 2.58^a	495.33 ± 12.02	378.66 ± 5.56^a	330.33 ± 15.51^a	147.33 ± 4.77^a^,^x^,^p
GSH (nmol/mg protein)	0.0051 ± 0.00020	0.0015 ± 0.00011^*	0.0051 ± 0.00016^a	0.0016 ± 9.38E-50	0.0029 ± 2.72E-04^a	0.0038 ± 0.00011^a	0.0053 ± 1.69E-03^a^,^x^,^p
MDA (nmol/mg protein)	0.252 ± 0.014	0.563 ± 0.019^*	0.228 ± 0.011^a	0.558 ± 0.020	0.424 ± 0.010^a	0.396 ± 0.007^a	0.208 ± 0.08^a^,^x^,^p
AchE (nmol/min/g protein)	38.82 ± 1.24	65.24 ± 2.05^*	36.68 ± 1.92^a	64.79 ± 3.90	64.74 ± 1.68	64.25 ± 3.11	62.67 ± 1.41^#
Dopamine (pg/mg brain)	427.38 ± 27.11	981.73 ± 30.68^*	429.62 ± 29.03^a	978.40 ± 25.40	688.33 ± 21.12^a	642.93 ± 27.21^a	435.16 ± 21.55^a^,^x^,^p
GABA (μg/g brain)	192.58 ± 6.75	107.80 ± 6.06^*	208.88 ± 8.80^a	106.42 ± 6.11	147.50 ± 3.22^a	155.99 ± 3.56^a	211.30 ± 5.62^a^,^x^,^p

Values are expressed as mean ± SEM (n = 6).

p < .001 vs vehicle group.

^{^a}

p < .001 vs ketamine group.

^{^x}

p < .001 vs Keta + Doxy (25 mg/kg).

^{^p}

p < .001 vs Keta + Doxy (50 mg/kg).

^{^q}

p < .01 vs Keta + Doxy (50 mg/kg).

^{^#}

p < .001 vs olanzapine.

Keta: Ketamine; Olz: Olanzapine; Doxy: Doxycycline hydrochloride; DCNP_opt: Optimized Doxycycline hydrochloride Chitosan Nanoparticles.