Table 2. Pharmacokinetic parameters of DTZ in rats of groups A, B and C.

Parameter	Group A	Group B	Group C
Cmax (ng/mL)	220.08 ± 10.2	203.81 ± 12.07	244.66 ± 3.75
Tmax (h)	0.50 ± 0.08	1.00 ± 0	1.00 ± 0
MRT (h)	4.60 ± 0.57	4.54 ± 0.31	2.22 ± 0.07
Half Life (h)	3.06 ± 0.40	2.81 ± 0.21	1.46 ± 0.08
AUC 0–6h (ng.h.mL−1)	615.46 ± 38.25	642.14 ± 32.22	518.29 ± 6.37
AUC 0–∞ (ng.h.mL−1)	862.26 ± 95.42	876.41 ± 27.59	550.06 ± 6.87
AUMC 0–6h (ng.h2.mL−1)	1490 ± 38.25	1569.79 ± 32.22	1034.69 ± 6.37
AUMC 0–∞ (ng.h2.mL−1)	4229.71 ± 864.02	3989.15 ± 313.58	1334.45 ± 97.86
Ke (h−1)	0.25 ± 0.04	0.25 ± 0.02	0.48 ± 0.02
Cmax/AUC 0–∞ (h−1)	0.28 ± 0.04	0.23 ± 0.012	0.45 ± 0.01