Table 1.
Composition of prepared MSP-PLCPs, percent yield, n-octanol/water partition coefficient (P), water solubility, n-octanol solubility, in vitro mucoadhesion time particles size, and PDI of MSP and MSP-PIPs.
| Formula | Phospholipid type (PL) | Molar ratio (MSP:PL) | Yield (%) ± SDa | P ± SDa | Log P | Solubility in water (mg/ml) ±SDa | Solubility in n-octanol (mg/ml) ±SDa | In vitro flushing resistance time (s)±SDa | Particle size (z-average nm)±SDa | PDI ± SDa |
|---|---|---|---|---|---|---|---|---|---|---|
| MSP | – | – | – | 5.74 ± 0.08 | 0.76 | 1.34 ± 0.13 | 1.88 ± 0.39 | 7.00 ± 1.41 | – | – |
| CP 1 | SB 1 | 1:1 | 60.79 ± 5.78 | 19.46 ± 1.98 | 1.29 | 0.71 ± 0.02 | 2.56 ± 0.09 | 62.50 ± 10.60 | 372.70 ± 21.78 | 0.36 ± 0.029 |
| CP 2 | SB 1 | 1:2 | 76.87 ± 1.37 | 8.95 ± 0.13 | 0.95 | 0.72 ± 0.05 | 1.74 ± 0.21 | 150.00 ± 14.14 | 246.25 ± 6.86 | 0.38 ± 0.017 |
| CP 3 | SB 2 | 1:1 | 90.90 ± 2.27 | 62.33 ± 2.62 | 1.79 | 0.68 ± 0.08 | 3.94 ± 0.55 | 26.50 ± 4.94 | 356.95 ± 47.45 | 0.27 ± 0.019 |
| CP 4 | SB 2 | 1:2 | 96.06 ± 0.187 | 49.21 ± 9.94 | 1.69 | 0.32 ± 0.01 | 4.23 ± 0.14 | 99.00 ± 21.21 | 268.80 ± 1.56 | 0.40 ± 0.006 |
a
All readings are average of three replicates.