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. 2017 Sep 21;24(1):1401–1409. doi: 10.1080/10717544.2017.1378940

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — In vivo distribution and anti-GBM efficacy of nanoparticles in U87MG glioma-bearing nude mice. (A) In vivo real-time fluorescence imaging of U87MG glioma-bearing nude mice administrated with DiR-labeled NP, CREKA-NP, Pep-NP and PC-NP at two different time points (4 h and 24 h). (B) (C) Ex vivo fluorescence imaging of organs and brains sacrificed 24 h after treatment. (D) In vivo distribution of various coumarin-6-loaded nanoparticles in glioma sections of U87MG glioma-bearing nude mice. Dash lines: border of the glioma. Original magnification: ×20. (E) Kaplan–Meier survival curves for U87MG glioma-bearing mice treated with different PTX formulations at a dose of 10 mg/kg PTX on day 2, 4, 6 and 8 post-implantations.