Table 1. Composition and pre-compression characterization of risperidone liquisolid formulae.
Formula | Vehicle type | LDCa | Lf | Q | q | Disb | Unit dose weight (mg) | Angle of repose | Ci% | Hausner ratio |
---|---|---|---|---|---|---|---|---|---|---|
F1 | Transcutol HP | 10 | 0.243 | 165 | 8.25 | 17.325 | 192.48 | 32.22 | 17.84 | 1.21 |
F2 | 20 | 83 | 4.15 | 8.715 | 96.82 | 31.16 | 19.16 | 1.19 | ||
F3 | 30 | 55 | 2.75 | 5.775 | 64.16 | 31.62 | 18.18 | 1.18 | ||
F4 | Labrasol | 10 | 0.202 | 198 | 9.9 | 20.76 | 230.64 | 30.12 | 17.67 | 1.17 |
F5 | 20 | 99 | 4.95 | 10.395 | 115.49 | 29.86 | 16.16 | 1.19 | ||
F6 | 30 | 66 | 3.3 | 6.93 | 76.994 | 30.25 | 16.87 | 1.16 | ||
F7 | PEG 400 | 10 | 0.104 | 385 | 19.25 | 40.425 | 449.12 | 31.12 | 20.01 | 1.12 |
F8 | 20 | 193 | 9.65 | 20.265 | 225.14 | 31.24 | 18.79 | 1.14 | ||
F9 | 30 | 128 | 6.4 | 13.44 | 149.32 | 32.11 | 18.89 | 1.17 | ||
F10 | Tween 80 | 10 | 0.142 | 282 | 14.1 | 29.61 | 328.97 | 30.35 | 18.13 | 1.20 |
F11 | 20 | 141 | 7.05 | 14.805 | 164.43 | 31.63 | 18.87 | 1.18 | ||
F12 | 30 | 94 | 4.7 | 9.87 | 109.66 | 32.15 | 17.82 | 1.19 | ||
F13 | Labrasol/Labrafil (1:1) | 10 | 0.151 | 265 | 13.25 | 27.825 | 309.14 | 30.75 | 18.92 | 1.17 |
F14 | 20 | 133 | 6.65 | 13.965 | 155.15 | 31.41 | 19.37 | 1.17 | ||
F15 | 30 | 89 | 4.45 | 9.345 | 103.82 | 31.82 | 19.41 | 1.16 |
aLiquid drug concentration.
Disintegrant amount (mg).