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. 2017 Nov 28;24(1):1843–1855. doi: 10.1080/10717544.2017.1386731

Figure 3.

Figure 3.

BBB pathological leakage provided an effective pathway for Ap-CSSA/DOX nanoparticles crossing the barrier and GBM cascade-targeting in vitro. An in vitro physiological BBB model (A) and pathological BBB model (B). (C) Effect of VEGF/VEGFR signal pathway on claudin-5 expression in the bEnd.3 cells observed by confocal imaging (Scale bar =30 μm). (D) The fluorescence intensity of claudin-5 signal measured by Image J (n = 3). (E) Cascade-targeting capacity of CSSA/DOX and Ap-CSSA/DOX nanoparticles in U87 MG cells at pathological BBB model (Scale bar =30 μm). (F) The transport ratios of CSSA/DOX and Ap-CSSA/DOX nanoparticles across the physiological BBB mode and pathological BBB model in vitro over a period of 1 h, 4 h (n = 3).