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. 2017 Nov 28;24(1):1843–1855. doi: 10.1080/10717544.2017.1386731

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Antitumor activity. (A) In vivo bioluminescence imaging of U87-luci bearing nude mice at different time points after treatment (day 4, 7, 10, 13). (B) Quantitative of signals from the entire abdominal region of each mouse (n = 3). (C) Kaplan–Meier survival curves (n = 6). (D) Body weight changes exposed to various treatment (n = 6). In vivo distribution of DOX-loaded nanoparticles in the margin (E) and center areas (F) of the orthotopic brain tumor. (G) H and E staining of brain tumor sections and heart sections after the i.v. injection with saline, DOX·HCl, CSSA/DOX and Ap-CSSA/DOX nanoparticles, respectively.