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. 2017 Nov 28;24(1):1843–1855. doi: 10.1080/10717544.2017.1386731

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scheme 1. — Transport routes of Ap-CSSO/DOX nanoparticles crossing the BBB. (A) Normal BBB with integrated TJs. (B) TJs was completely broken in GBM tissues. (C) The margin between normal brain tissues and GBM, TJs was slightly disrupted.