Table 1.
Composition of atorvastatin-loaded nanostructured lipid carriers.
| AT-NLCs compositiona |
Physicochemical properties |
|||||
|---|---|---|---|---|---|---|
| Run | Solid lipid (2%, w/w) | Aqueous surfactant (2%, w/w) | Mean particle size ± SD (nm) | Zeta potential ± SD (mV) | Entrapment efficiency ± SD (%) | Polydispersity index (PDI) |
| NLC-1 | Gelucire® 43/01 | Pluronic® F68 | 162.5 ± 12 | −34 ± 0.29 | 90.1 ± 6.5 | 0.295 |
| NLC-2 | Gelucire® 43/01 | Tween® 80 | 199.14 ± 22 | −31 ± 0.50 | 91.3 ± 5.9 | 0.434 |
| NLC-3 | Gelucire® 43/01 | Pluronic® F68–Tween® 80 (1:1) | 168.54 ± 14 | −31 ± 0.25 | 87.2 ± 7.5 | 0.261 |
| NLC-4 | GMS | Pluronic® F68 | 184.98 ± 21 | −29 ± 2.8 | 95.3 ± 5.1 | 0.276 |
| NLC-5 | GMS | Tween® 80 | 234 ± 6.8 | −28 ± 2.9 | 92.2 ± 6.2 | 0.451 |
| NLC-6 | GMS | Pluronic® F68–Tween® 80 (1:1) | 254.4 ± 32.1 | −29 ± 2.25 | 87 ± 4 | 0.571 |
| NLC-7 | Compritol® 888 ATO | Pluronic® F68 | 865.55 ± 28 | −28 ± 0.85 | 94.6 ± 2.6 | 0.732 |
| NLC-8 | Compritol® 888 ATO | Tween® 80 | 224.7 ± 7.5 | −23 ± 0.36 | 76 ± 12.4 | 0.62 |
| NLC-9 | Compritol® 888 ATO | Pluronic® F68–Tween® 80 (1:1) | 449.4 ± 3 | −24 ± 0.54 | 96.6 ± 7.1 | 0.691 |
a
Each formulation contains 8%, w/w Capryol® PGMC and 0.5%, w/w lecithin.