Table 5. Pharmacokinetic parameters of puerarin in mice brain after administration of NCS, ICS and SMEDDS containing both of puerarin (200 mg/kg) and borneol (100 mg/kg) (n = 6).
Parameters | NCS | SMEDDS | ICS |
---|---|---|---|
AUC(0–12 h) (ng/mL × h) | 1303.75 ± 387.47 | 2199.81 ± 328.98b | 1488.09 ± 299.92c |
t1/2 (h) | 4.30 ± 1.63 | 5.71 ± 1.03 | 2.20 ± 0.49a,d |
Tmax (h) | 1.13 ± 0.60 | 0.85 ± 0.22 | 0.75 ± 0.18 |
Cmax (ng/mL) | 220.25 ± 69.29 | 462.48 ± 55.75b | 385.94 ± 84.61a |
ap < 0.05 compared with NCS.
p < 0.01 compared with NCS.
p < 0.05 compared with SMEDDS.
p < 0.01 compared with SMEDDS.