Figure 5.

Elimination routes of intraperitoneally administered nab-paclitaxel are affected by angiogenesis inhibition. Nude mice were treated with 40 mg/kg DC101 or PBS control therapy twice a week for four weeks followed by an intraperitoneal injection of 120 mg/kg NPTX. Of all mice, the (A) intraperitoneal cavity lavage (B) urine, (C) liver, and (D) kidney were collected and NPTX concentrations were determined using LC–MS/MS. Scatter dot plots show the mean ± SD, n = 3 per group. *p < .05 was determined by two-sided unpaired t-tests and analyzed against untreated control.