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Pharmacokinetic parameters of DH following the oral administration of Cymbalta® capsules and buccal administration of F2 (Mean ± SD).
| Pharmacokinetic parameter | Cymbalta® 30 mg capsule | F2 films |
|---|---|---|
| Cmax (ng/ml) | 54.10 ± 33.83 | 89.33 ± 34.21 |
| Tmax (h) | 5.67 ± 1.86 | 3.5 ± 0.84 |
| AUC0–t (ng h/ml) | 518.5 ± 333.32 | 1536.8 ± 931.45 |
| AUC0–∞ (ng h/ml) | 535.09 ± 337.01 | 1646.17 ± 1043.7 |
| MRT (h) | 20.99 ± 4.8 | 22.36 ± 4.32 |
| K (1/h) | 0.05 ± 0.01 | 0.05 ± 0.01 |
| Relative bioavailability (%) | – | 296.39 |
