Table 2.
Pharmacokinetics parameters of Cur after gavage administration of Cur solution, Cur-loaded NLC and NAPG-NLC at a dose of 50 mg/kg of Cur and intravenous injection of Cur solution at a dose of 2 mg/kg of Cur in rats (mean ± SD; n = 6).
| Pharmacokinetics parameters | Cur solution (p.o.) | Cur solution (i.v.) | Cur-NLC | Cur-NAPG20-NLC | Cur-NAPG50-NLC | Cur-NAPG100-NLC |
|---|---|---|---|---|---|---|
| Cmax1(µg/mL) | 0.022 ± 0.006 | – | 1.05 ± 0.26* | 3.76 ± 0.90*# | 10.45 ± 1.44△□ | 20.71 ± 2.40△□ |
| Cmax2(µg/mL) | – | – | – | 3.25 ± 1.34 | 5.78 ± 1.78 | 17.36 ± 1.57 |
| AUC0–10 h (µg h /mL) | 0.11 ± 0.04 | 0.17 ± 0.06 | 0.47 ± 0.21* | 8.91 ± 2.83*# | 16.61 ± 2.48△□ | 54.94 ± 3.82△□ |
| MRT (h) | 1.41 ± 0.25 | – | 1.57 ± 0.08 | 2.07 ± 0.68*# | 2.64 ± 0.36△□ | 2.90 ± 0.40△□ |
| CL (L/h) | 68.97 ± 3.47 | – | 20.87 ± 2.75* | 1.12 ± 0.11*# | 0.61 ± 0.24△□ | 0.18 ± 0.08△□ |
| FAbs ×100 | 2.60 ± 1.03 | 100.00 | 11.01 ± 4.86 | 209.49 ± 66.48 | 391.24 ± 58.30 | 1293.33 ± 89.84 |
– no data.
*
p < .05 compared with Cur solution.
△
p < .01 compared with Cur solution.
#
p < .05 compared with Cur-NLC.
□
p < .01 compared with Cur-NLC.