. 2017 May 22;24(1):834–845. doi: 10.1080/10717544.2017.1326540

Table 2. Pharmacokinetic parameters of celastrol formulations after i.v. administration at dose of 3 mg/kg (data are presented as mean ± SD, n = 4).

Parameter	CG-M	CG-M_blank	C + G
Half-time (min)	445.3 ± 43.5^**	251.1 ± 13.5	219.1 ± 13.5
MRT ^a _0-∞ (min)	606.2 ± 73.1^**	410.2 ± 13.5	284.8 ± 19.3
AUC ^b _0-∞ (ng/mL/h)	645060.8 ± 63640.7^**	292218 ± 2290.75	187501.6 ± 17924.7
C_max (ng/mL)	2421.6 ± 285.2^**	294.3 ± 35.2	1836.3 ± 209.2
T_max (min)	5	360	5

^aMRT _0-∞, mean residence time; ^bAUC _0-∞, area under the plasma concentration–time curve.

^**

p < 0.01 versus C + G.