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. 2017 Sep 15;24(1):1350–1359. doi: 10.1080/10717544.2017.1377317

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Preparation and characterization of FK506_M. (a) Scanning electron microscopy, scale bar =10 μm. (b) X-ray powder diffraction (XRD). (c) Differential scanning calorimetry (DSC). (d) Fourier transform infrared spectrometry (FTIR). (e) In vitro release of FK506 from FK506_M in phosphate--buffered saline (pH 7.4) containing 0.5% Tween 20. The solid line indicates release profile of FK506 when the microspheres were incorporated with Matrigel and the dotted line indicates the release profile without Matrigel. The values represent means ± standard deviations (SD), n = 3. (f) In vitro cytotoxicity (MTT) assays of blank PLGA microspheres on INS-1 cells. The values represent means ± SD, n = 8.