Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 15;15:685645. doi: 10.3389/fnins.2021.685645

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Dieu, Wais, Sørensen, Marczynska, Dubik, Kavan, Thomassen, Burton, Kruse, Khorooshi and Owens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Intrathecal CpG induced inflammation-associated cytokines and chemokines. To investigate how intrathecal CpG influences CNS inflammatory programs in healthy mice, expression of inflammation-associated mediators was analyzed by RNAseq and RT-pPCR. (A) Heatmap of RNAseq analysis of CpG-induced CNS. Intrathecal CpG induced significant upregulation of 29 genes in the brain (LogFC ≥ 2 and adjusted p-value ≤ 0.05). These genes include type I IFN response genes as well as chemokines. (B) Bar graphs show levels of CCL2, IFNγ, and IL10 mRNA in brains and spinal cords 4 h post injection (n = 3–5 per group). Results were analyzed using the two-tailed Mann–Whitney U-test. Data are presented as means ± SD. *p < 0.05.