Figure 5.

Bcl2 enhances high-LET irradiation-induced lung tumorigenesis. (a) Wild-type C57BL/6 mice and lung-targeting Bcl2 transgenic mice were exposed to 0.5 Gy of X-ray, ⁵⁶Fe, ²⁸Si or proton once a day for 5 days continuously, followed by monitoring lung tumorigenesis for 18 months. Percentage of lung cancer incidence was calculated for all groups. Number of mice (n) for each group is indicated in Supplementary Table 2, **P < 0.01, ***P < 0.001, ns, no significance, by 2-tailed t-test. (b) Tumor numbers were counted under the microscope and tumor area was quantified using Openlab modular imaging software. The error bars indicate ± SD, number of mice (n) for each group is indicated in Supplementary Table 2. **P < 0.01, ***P < 0.001, ns, no significance, by 2-tailed t-test. (c) Representative H&E images from no treatment or treatment groups for wild-type C57BL/6 and lung-targeting Bcl2 transgenic mice.