Table 2.
Cox univariable and multivariable analysis of factors predictive of overall survival in the entire cohort
| Characteristic | Univariate analysis | P Value | Multivariate analysis | p-value | ||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% Confidence Interval | Hazard ratio | 95% confidence interval | |||
| HER2-targeted therapy | ||||||
| No | 1 (reference) | 1 (reference) | ||||
| Yes | 0.360 | 0.128–1.010 | 0.052 | 0.348 | 0.124–0.981 | 0.046 |
| Age (years) | ||||||
| ≤ 50 | 1 (reference) | 1 (reference) | ||||
| > 50 | 2.617 | 0.932–7.349 | 0.068 | 2.050 | 0.722–5.819 | 0.177 |
| Charlson-Deyo Score | ||||||
| 0 | 1 (reference) | 1 (reference) | ||||
| 1 | 1.956 | 0.863–4.433 | 0.108 | 1.878 | 0.821–4.295 | 0.136 |
| ≥ 2 | 3.820 | 0.914–15.964 | 0.066 | 4.331 | 1.008–18.608 | 0.049 |
| Facility type | ||||||
| Academic | 1 (reference) | – | – | – | ||
| Non-academic | 1.029 | 0.516–2.054 | 0.934 | – | – | – |
| Surgical margins | ||||||
| Negative | 1 (reference) | – | – | – | ||
| Positive | 1.566 | 0.378–6.493 | 0.536 | – | – | – |
| Hormonal therapy | ||||||
| Yes | 1 (reference) | 1 (reference) | ||||
| No | 2.909 | 1.425–5.940 | 0.003 | 2.316 | 1.005–5.334 | 0.049 |
| Estrogen receptor status | ||||||
| Positive | 1 (reference) | 1 (reference) | ||||
| Negative | 1.852 | 1.004–3.418 | 0.049 | 1.301 | 0.629–2.693 | 0.478 |
| Progesterone receptor status | ||||||
| Positive | 1 (reference) | – | – | – | ||
| Negative | 1.356 | 0.724–2.538 | 0.342 | – | – | – |
| Grade | ||||||
| 1 | 1 (reference) | – | – | – | ||
| 2 | 2.008 | 0.251–16.068 | 0.511 | – | – | – |
| 3 | 1.978 | 0.268–14.593 | 0.503 | – | – | – |
| Not recorded | 1.659 | 0.199–13.806 | 0.640 | – | – | – |