Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nasopharyngeal viral ribonucleic acid (RNA) copy number and antibody status in children with acute coronavirus disease 2019 (COVID-19), with multisystem inflammatory syndrome in children (MIS-C), and those without confirmed SARS-CoV-2 infection. Statistically significant values are denoted with a star (*). The dark line indicates the median. (A) Nasopharyngeal SARS-CoV-2 viral RNA [log2(copies/mL)] to N1 of SARS CoV-2 in children with MIS-C (N = 6), with acute COVID-19 (N = 13), and unconfirmed (N = 11). Similar values were seen for N2 (data not shown). Values at zero denote those that are below the limit of quantitation (<1.25 copies/mL) by ddPCR. (B) Plasma immunoglobulin G concentrations (absorbance units) in children with MIS-C (N = 15), with acute COVID-19 (N = 10), and unconfirmed (N = 12). Values at zero denote those that are below the limit of detection (<1.23 absorbance units) of the EUROIMMUN ELISA.