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. 2021 Jun 22;2021:5543531. doi: 10.1155/2021/5543531

Table 2.

Area under the curve (AUC) of malondialdehyde (MDA) and DNA/RNA oxidation products between the controls and incidentaloma and pheochromocytoma, as well as Cushing's/Conn's adenoma patients, pheochromocytoma and incidentaloma patient, pheochromocytoma and Cushing's/Conn's adenoma patients, incidentaloma and Cushing's/Conn's adenoma patients.

AUC 95% CI p value Cutoff Sensitivity % 95% CI Specificity % 95% CI
Controls vs. incidentaloma
 MDA 0.8594 0.7856 to 0.9333 <0.0001 > 135.2 76.67 59.07% to 88.21% 75 62.77% to 84.22%
 DNA/RNA oxidation products 0.7694 0.6535 to 0.8853 <0.0001 > 1.255 73.33 55.55% to 85.82% 71.67 59.23% to 81.49%
Controls vs. pheochromocytoma
 MDA 0.99 0.9732 to 1.000 <0.0001 > 180.2 95 76.39% to 99.74% 96.67 88.64% to 99.41%
 DNA/RNA oxidation products 0.9908 0.9765 to 1.000 <0.0001 > 1.587 95 76.39% to 99.74% 95 86.30% to 98.64%
Controls vs. Cushing's/Conn's adenoma
 MDA 0.8483 0.7636 to 0.933 <0.0001 > 136.7 75 53.13% to 88.81% 76.67 64.56% to 85.56%
 DNA/RNA oxidation products 0.6842 0.5380 to 0.8303 0.0141 > 1.185 60 38.66% to 78.12% 58.33 45.73% to 69.94%
Pheochromocytoma vs. incidentaloma
 MDA 0.8467 0.7400 to 0.9533 <0.0001 > 201.2 75 53.13% to 88.81% 76.67 59.07% to 88.21%
 DNA/RNA oxidation products 0.825 0.7079 to 0.9421 0.0001 > 1.927 75 53.13% to 88.81% 76.67 59.07% to 88.21%
Pheochromocytoma vs. Cushing's/Conn's adenoma
 MDA 0.8325 0.6923 to 0.9727 0.0003 < 201.2 75 53.13% to 88.81% 75 53.13% to 88.81%
 DNA/RNA oxidation products 0.9025 0.8086 to 0.9964 <0.0001 < 1.752 80 58.40% to 91.93% 80 58.40% to 91.93%
Incidentaloma vs. Cushig's/Conn's adenoma
 MDA 0.525 0.3575 to 0.6925 0.7664 < 161.7 55 34.21% to 74.18% 53.33 36.14% to 69.77%
 DNA/RNA oxidation products 0.5983 0.4371 to 0.7596 0.2427 < 1.471 55 34.21% to 74.18% 56.67 39.20% to 72.62%