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HPD according to ROC curves.
| Tumor types | Characteristic tumor markers | Cut-off values | Sensitivity | Specificity | P value |
|---|---|---|---|---|---|
| Lung squamous carcinoma | CYFRA211/NSE/SCC | 12% | 100.0% | 78.8% | 0.022 |
| Lung adenocarcinoma | CEA/CA125 | 29% | 87.5% | 65.2% | <0.01 |
| Colorectal cancer | CA125/CA724/CA199/CEA | 49% | 100.0% | 93.7% | <0.01 |
| Pancreatic cancer | CA199 | 167% | 85.7% | 94.1% | <0.01 |
| Cholangiocarcinoma | CA199 | 126% | 100.0% | 91.7% | 0.034 |
HPD: hyperprogressive disease; ROC: receiver operating characteristic.
