Table 2.

Antifungal activity of isavuconazole and comparator antifungal agents against Aspergillus spp. collected during 2011–2019 in APAC medical centers participating in the SENTRY Antifungal Surveillance Program

Species	Antifungal agent (no. tested)	MIC (µg ml−1)			ECV
		Range	50%	90%	%WT	%NWT
Aspergillus spp.	Isavuconazole (126)	0.015–4	0.5	2
	Itraconazole (319)	0.12–>8	0.5	1
	Posaconazole (319)	0.03–>8	0.25	0.5
	Voriconazole (319)	0.03–4	0.5	1
A. fumigatus	Isavuconazole (70)	0.25–2	0.5	1	94.3	5.7
	Itraconazole (189)	0.25–>8	0.5	1	97.9	2.1
	Posaconazole (189)	0.03–>8	0.25	0.5	98.9a	1.1
	Voriconazole (189)	0.06–4	0.5	0.5	98.9	1.1
A. flavus SC	Isavuconazole (19)	0.5–2	0.5	1	94.7	5.3
	Itraconazole (43)	0.25–1	0.5	1	100.0	0.0
	Posaconazole (43)	0.12–1	0.25	0.5	97.7	2.3
	Voriconazole (43)	0.12–2	0.5	1	100.0	0.0
A. niger SC	Isavuconazole (18)	0.12–4	2	4	100.0	0.0
	Itraconazole (46)	0.12–8	1	2	97.8	2.2
	Posaconazole (46)	0.06–1	0.5	1	100.0	0.0
	Voriconazole (46)	0.06–2	1	1	100.0	0.0
A. terreus SC	Isavuconazole (6)	0.06–0.5	0.12		100.0	0.0
	Itraconazole (14)	0.25–1	0.5	1	100.0	0.0
	Posaconazole (14)	0.12–0.5	0.25	0.25	100.0	0.0
	Voriconazole (14)	0.06–0.5	0.25	0.5	100.0	0.0
A. nidulans SC	Isavuconazole (6)	0.015–0.25	0.03
	Itraconazole (11)	0.12–1	0.5	0.5
	Posaconazole (11)	0.06–0.5	0.25	0.5
	Voriconazole (11)	0.03–0.5	0.12	0.25
A. tamari	Isavuconazole (2)	0.12–0.25	0.12
	Itraconazole (3)	0.25–0.5	0.25
	Posaconazole (3)	0.06–0.25	0.12
	Voriconazole (3)	0.12–0.5	0.25
A. versicolor	Isavuconazole (1)	0.5
	Itraconazole (3)	0.5–1	0.5
	Posaconazole (3)	0.5	0.5
	Voriconazole (3)	0.25–0.5	0.5

SC species complex

^aUsing an ECV of ≤0.5 mg l⁻¹ [40].