Table 4.
Antifungal activity of isavuconazole and comparator antifungal agents for non-Aspergillus mold isolates collected during 2011–2019 in Asia-Western Pacific medical centers participating in the SENTRY Antifungal Surveillance Program
| Organism | MIC results in mg l−1a | ||
|---|---|---|---|
| Isavuconazole | Posaconazole | Voriconazole | |
| Fusarium solani species complex | >8 | >8 | >8 |
| Fusarium solani species complex | >8 | >8 | 4 |
| Fusarium solani species complex | >8 | >8 | 8 |
| Fusarium solani species complex | NT | >8 | >8 |
| Lichtheimia corymbifera | 2 | 0.5 | >8 |
| Lichtheimia ramosa | NT | 1 | >8 |
| Lichtheimia ramosa | NT | 0.5 | >8 |
| Mucor circinelloides | NT | 2 | >8 |
| Rhizomucor pusillus | NT | 0.5 | >8 |
| Rhizopus microsporus group | 2 | 2 | >8 |
| Rhizopus microsporus group | 2 | 0.5 | >8 |
| Rhizopus oryzae SC | >8 | 1 | >8 |
| Rhizopus oryzae SC | >8 | 2 | >8 |
| Rhizopus oryzae SC | >8 | 4 | >8 |
| Rhizopus oryzae SC | NT | 0.5 | >8 |
| Cunninghamella sp. | 8 | 1 | >8 |
| Syncephalastrum sp. | 2 | 0.5 | >8 |
| Scedosporium apiospermum | NT | 1 | 1 |
| Scedosporium apiospermum/S. boydii | NT | 1 | 0.12 |
| Scedosporium apiospermum/S. boydii | NT | 0.5 | 0.5 |
| Scedosporium apiospermum/S. boydii | 4 | 1 | 0.5 |
| Scedosporium apiospermum/S. boydii | 4 | 2 | 0.5 |
| Scedosporium apiospermum/S. boydii | 4 | 4 | 0.5 |
| Scedosporium apiospermum/S. boydii | NT | 2 | 1 |
| Scedosporium apiospermum/S. boydii | >8 | 2 | 1 |
| Scedosporium apiospermum/S. boydii | 8 | 2 | 4 |
| Scedosporium apiospermum/S. boydii | 1 | >8 | 8 |
| Scedosporium aurantiacum | NT | 2 | 0.5 |
| Scedosporium aurantiacum | NT | 2 | 0.5 |
| Scedosporium aurantiacum | 8 | 2 | 0.5 |
| Scedosporium aurantiacum | 8 | 2 | 0.5 |
| Scedosporium aurantiacum | NT | 2 | 1 |
| Scedosporium aurantiacum | NT | 2 | 1 |
| Scedosporium aurantiacum | NT | 2 | 1 |
| Exophiala dermatitidis | 1 | 0.25 | 0.25 |
| Lomentospora prolificans | NT | >8 | 8 |
| Lomentospora prolificans | NT | >8 | >8 |
| Lomentospora prolificans | NT | >8 | >8 |
| Lomentospora prolificans | NT | >8 | >8 |
| Lomentospora prolificans | >8 | >8 | >8 |
| Lomentospora prolificans | >8 | >8 | >8 |
| Purpureocillium lilacinum | 0.5 | 0.5 | 0.25 |
| Purpureocillium lilacinum | NT | >8 | 8 |
| Pleurostoma richardsiae | 0.5 | 0.5 | 0.5 |
| Rasamsonia argillacea | >8 | 2 | >8 |
| Trichoderma longibrachiatum | NT | 2 | 0.5 |
| Curvularia sp. | 0.5 | 0.25 | 0.5 |
| Curvularia sp. | 1 | 0.5 | 0.5 |
| Paecilomyces sp. | >8 | 0.25 | >8 |
| Paecilomyces sp. | >8 | 0.25 | >8 |
| Phaeoacremonium sp. | 2 | 0.5 | 0.5 |
| Phialemoniopsis sp. | 0.5 | 0.25 | 0.25 |
| Verruconis gallopava | 1 | 0.06 | 0.25 |
aNT not tested