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Kinase inhibitory properties of the promising antiproliferative 3-alkenyl-2-oxindoles (6a–c, 10a–c) synthesized and Sunitinib.
| Entry | Compd. | IC50 (nM ± SD) |
|
|---|---|---|---|
| VEGFR-2 | c-kit | ||
| 1 | 6a | 54.03 ± 5.4 | 119.8 ± 12.0 |
| 2 | 6b | 98.95 ± 9.9 | 247.7 ± 24.8 |
| 3 | 6c | 36.86 ± 3.7 | 72.35 ± 7.2 |
| 4 | 10a | 102.2 ± 10.2 | 103.3 ± 10.3 |
| 5 | 10b | 74.06 ± 7.4 | 184.9 ± 18.5 |
| 6 | 10c | 53.36 ± 5.3 | 81.7 ± 8.2 |
| 7 | Sunitinib | 47.54 ± 4.8 | 84.9 ± 8.5 |
