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. 2021 Jun 30;114:105131. doi: 10.1016/j.bioorg.2021.105131

Table 6.

Antiviral properties of the tested compounds against SARS-CoV-2.

Entry Compd. IC50 (µM)a CC50 (µM)b SIc
1 6a 3.799 1377 362.5
2 6b 55.14 1313 23.8
3 6c 13.52 356.9 26.4
4 10a 219 1617 7.4
5 10b 3.417 566 165.6
6 10c 20.1 1517 75.5
7 Hydroxychloroquine 29.25 356.4 12.2
8 Chloroquine 19.78 377.7 19.1
9 Favipiravir 1382 2633 1.9

aCC50 = Cytotoxic concentration due to 50% growth compared to the control experiment.

b IC50 = Inhibitory concentration due to 50% growth compared to the control experiment.

c SI (Selectivity index/therapeutical index) =CC50IC50