Table 6.
Entry | Compd. | IC50 (µM)a | CC50 (µM)b | SIc |
---|---|---|---|---|
1 | 6a | 3.799 | 1377 | 362.5 |
2 | 6b | 55.14 | 1313 | 23.8 |
3 | 6c | 13.52 | 356.9 | 26.4 |
4 | 10a | 219 | 1617 | 7.4 |
5 | 10b | 3.417 | 566 | 165.6 |
6 | 10c | 20.1 | 1517 | 75.5 |
7 | Hydroxychloroquine | 29.25 | 356.4 | 12.2 |
8 | Chloroquine | 19.78 | 377.7 | 19.1 |
9 | Favipiravir | 1382 | 2633 | 1.9 |
aCC50 = Cytotoxic concentration due to 50% growth compared to the control experiment.
b IC50 = Inhibitory concentration due to 50% growth compared to the control experiment.
c SI (Selectivity index/therapeutical index) =