Table 2.

Details of treatment condition.

Study (Publication Year)	SSNHL Definition	Drug		Mode of administration		Duration fo Treatment		Dose and Frequency		adjuvant therapy
		T	C	T	C	T	C	T	C	T	C
[1]Chen, 2018	At least 20 dB hearing lossin 2 CFs occurring within 3 days	MP	MP	auripuncture injection	IV	10d	NA	0.5～0.7 mL/d every other day for 5 times	40 g/L:8mg/(kg·d);reduced and stopped gradually after 6 days	all patients received vasodilators and neurotrophic agents
[2]Gülce et al., 2017	At least 20 dB hearing lossin 3 CFs occurring within 3 days	DEX	P	auripuncture injection	oral	6d	NA	8mg/2 mL, 0.5–0.7 cc, 3 times every other day	1 mg/kg (maximum 80 mg) and tapering 10 mg every 3 days	All patients received the standard treatment protocol of our institu_×005f tion for SSHL; intravenous low molecular weight dextran (5 cc/kg) for 5–10 days, an oral diuretic agent (acetazola mide) for a month, an oral antiviral agent (acyclovir) for 5 days, an oral vasodilator agent (betahistine), and an oral cytoprotective agent (trimetazidine) for 3 months.
[3]Hong et al., 2009	At least 20 dB hearing lossin 3 CFs occurring within 3 days	DEX	P	auripuncture injection	oral	8d	8d	5 mg/mL, 0.3–0.4 cc once a day	60 mg for 4 days followed by 40 mg for 2 days and 20 mg for 2 days	treating with other medications, such as a peripheral vasodilator and ginkgo biloba extract
[4]Liang et al., 2012	At least 20 dB hearing lossin 2 CFs occurring within 3 days	DEX	P	Eustachian tube injection	IV/oral	10d	37d	5 mg/mL, every other day for 5 times	IV:10 mg/d DX for 7 days and followed by oral P 30 mg/d, reduce 5 mg every 7 days	intravenous Ginato 87.5 mg/d for 14 days and
[5]LI Hui et al., 2013	At least 20 dB hearing lossin 2 CFs occurring within 3 days	DEX	DEX	auripuncture injection	IV	10d	14d	5 mg/mL, 1 mL/d once a day	10 mg/d for 7 days, halve the dosage for another 7 days	IV:shuxuening injection 20 mL/d and Vinpocetine 30 mg/d; intramuscular injection: Vitamin1 0.1 g/d and Vitamin12 0.5 mg/d for 2 weeks
[6]Lim, 2013	At least 20 dB hearing lossin 3 CFs occurring within 3 days	DEX	P	auripuncture injection	oral	14d	10d	5 mg/mL,0.3–0.4 mL, twice a week for 2 weeks, for a total of 4 times	60 mg/d for 5 days,40 mg/d for 2 days,20 mg/d for 2 days, and 10 mg/d for 1 day	NA
[7]LI Zhi et al., 2015	At least 20 dB hearing lossin 2 CFs occurring within 3 days	Steroids		auripuncture injection	oral	10d	10d	5 mg/mL, every other day for 5 times	1mg/(kg·d)	all patients received vasodilators and neurotrophic agents
[8]Michael, 2018	At least 20 dB hearing lossin 3 CFs occurring within 3 days	MP	P	auripuncture injection	IV/oral	10d	17d	62.5 mg/mL, 0.4–0.6 mL every day for 1, 3, 5, 10 days after presentation(total of 4 times)	IV,P 1 mg/(kg·d)for 7 days followed by 0.5mg/(kg·d)for another 3 days;then oral MP:32 mg/d for 4 days followed by oral MP 16 mg/d for another 3 days	NA
[9]Peng et al., 2008	At least 20 dB hearing lossin 2 CFs occurring within 3 days	DEX	DEX	auripuncture injection	oral	10d	10d	5 mg/d, once a day for 10 times	0.75mg × 3/d for 7 dyas and 0.75 × 2 for another 2 days	IV:Low molecular dextran 500 mL, buflomedil 0.2g, intramuscular injection: Vitamin1 0.1 g/d and Vitamin12 0.5 mg/d for 10d or 20d
		DEX	DEX	Eustachian tube injection	IV	10d	10d	5 mg/d for 10 times	10 mg for 4 days and halve the dosage for another 6 days
[10]Qu et al., 2015	NA	MP	MP	auripuncture injection	IV	10d	7d	40 mg/d every other day for 10 days	80 mg/d for 4 days and reduced to 40 mg/d for another 3 days	all patients received vasodilators and neurotrophic agents
[11]Tang et al., 2015	NA	DEX	DEX	auripuncture injection	IV	12d	6d	5 mg/d every 3 day for 4 times	10 mg/d for 3 days and halve the dosage for another 3 days	IV:Cinepazide maleate 240 mg/d, ginkgo leaf extract and dipyridamole 30 mL/d, mecobalamin 0.5 mg/d;Oral:flururizine gum capsule,5 mg/d for 10 days
[12]Zhang et al., 2016	At least 20 dB hearing lossin 2 CFs occurring within 3 days	MP	P	auripuncture injection	oral	7d	7/14d	0.4–1 mL/d, 7 times of treatment	60 mg/d for 4 days, reduce 10 mg every 2 days to stop drug	IV:Ginaton 105 mg/d for 7 days or 14 days
[13]Rauch, 2011	hearing loss with onset in less than 72 h	MP	P	auripuncture injection	oral	2W	19d	40 mg/mL every 3–4 days for 1 times	60 mg/d for 14 days, followed by a 5-day taper(50 mg, 40 mg, 30 mg, 20 mg and to 10 mg)	NA
[14]Kosyakov et al., 2011	At least 20 dB hearing lossin 3 CFs occurring within 3 days	DEX	DEX	auripuncture injection	IV	6M	10d	4cc for 10 days, 4 mg/d for 20 days and 4 mg 2 times a week over 5 months	0.1mg/(kg·d)	NA
[15]Dispenza et al., 2011	At least 20 dB hearing lossin 3 CFs occurring within 3 days	P	DEX	auripuncture injection	oral	4W	14d	4 mg/mL weekly for a total of four injections	60 mg tapered	NA

T, Treatment group C, control group NA, not available MP, Methylprednisolone P, prednisone DEX, dexamethasone M, month d, day CF, continuous frequency PTA, pure tone average.