Table 3.
Summary of treatment outcomes.
| Study(Publication Year) | Criterion for hearing recovery |
Outcome(Recovery Rate[%]) |
PTA Before Treatment(dB) |
PTA Differences(dB) |
Frequency for PTA(kHz) |
Follow-up Period |
Results | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T | C | T | C | T | C | T | C | T | C | T | C | ||
| [1]Chen, 2018 | >15 dB improvement in PTA | 67.5 | 37.5 | 69.4 ± 14.6 | 69.5 ± 14.7 | NA | NA | NA | injection > IV | ||||
| [2]Gülce et al., 2017 | >10 dB improvement in PTA | 87.5 | 84.2 | NA | NA | 0.5, 1.0, and 2.0 | 3M | injection = oral | |||||
| [3]Hong et al., 2009 | >15 dB improvement in PTA | 75 | 72 | 77.5 ± 27.6 | 79.9 ± 23.5 | NA | 0.5, 1, 2 and 3 | 3M | injection = oral | ||||
| [4]Liang et al., 2012 | >15 dB improvement in PTA | 91.7 | 80 | 66.55 ± 16.52 | 66.2 ± 16.43 | NA | NA | 30d | Eustachian tube injection > IV/oral | ||||
| [5]LI Hui et al., 2013 | >15 dB improvement in PTA | 84.2 | 60.5 | 68.3 ± 23.5 | 63.2 ± 21.7 | NA | 0.5, 1, 2 and 4 | 1M | injection > IV | ||||
| [6]Lim, 2013 | >10 dB improvement in PTA | 55 | 60 | 58.9 ± 31.2 | 57.8 ± 28.5 | 12.1 ± 14.6 | 12.8 ± 15.4 | 0.5, 1, 2 and 3 | 3W | injection = IV | |||
| [7]LI Zhi et al., 2015 | >15 dB improvement in PTA | 81.3 | 75 | 64.5 ± 20.1 | 65.8 ± 18.7 | 13.9 ± 17.16 | 14.8 ± 16.5 | NA | NA | injection > IV | |||
| [8]Michael, 2018 | >15 dB improvement in PTA | 70.6 | 77.1 | 81.4 ± 23.3 | 81.1 ± 28.8 | 27 | 29 | 0.5, 1, 2 and 4 | 90d | injection = IV/oral | |||
| [9]Peng et al., 2008 | >15 dB improvement in PTA | 80.95 | 61.9 | 72.0 ± 18.6 | 69.0 ± 16.5 | 43.2 ± 21.5 | 21.3 ± 16.6 | 0.5, 1, 2 and 4 | 1W | injection/Eustachian tube injection > IV/oral | |||
| 85.7 | 66.7 | 71.0 ± 18.67 | 70.0 ± 17.6 | 48.1 ± 15.2 | 27.5 ± 14.5 | ||||||||
| [10]Qu et al., 2015 | >15 dB improvement in PTA | 80.7 | 78.26 | NA | NA | NA | NA | injction = IV | |||||
| [11]Tang et al., 2015 | NA | 84 | 68 | 85.4 ± 5.6 | 84.8 ± 5.6 | 53.7 ± 5.17 | 36.6 ± 5.28 | NA | 15d | injection > IV | |||
| [12]Zhang et al., 2016 | >15 dB improvement in PTA | 76.19 | 73.74 | 76.95 ± 15.49 | 78.08 ± 15.90 | 25.88 ± 14.46 | 22.85 ± 12.37 | NA | 8W | injection = IV | |||
| [13]Rauch, 2011 | >10 dB improvement in PTA | 76.7 | 84.3 | 86.4(82.8–90.0) | 86.7(82.9–90.6) | NA | NA | 2M | injection = oral | ||||
| [14]Kosyakov et al., 2011 | >15 dB improvement in PTA | 88 | 56 | 41.0 ± 12.87 | 39.1 ± 16.97 | 24.8 ± 5.83 | 14.0 ± 3.58 | 0.5, 1, 2 and 4 | 6M | 1 month treatment, injection = IV; Long-term treatment, injection > IV | |||
| [15]Dispenza et al., 2011 | >10 dB improvement in PTA | 80 | 81 | 65 | 51 | NA | 0.5, 1, 2, and 4 | 6M | injection = IV | ||||
T, Treatment group C, control group PTA, pure tone average NA, not available.