Table 2.
Effects of post-treatment with perampanel and diazepam i.p. 15 min following a 0.14 mg/kg, i.p., dose of TETS on the incidence of clonic and tonic seizures, tonic seizure severity, and the incidence of lethality at 1 h and 24 h
| Treatment (dose) | N | Clonic seizures after treatment | Tonic seizures | Mean tonic seizure severity | Dead 1 h | Dead or unsalvageable 24 h |
|---|---|---|---|---|---|---|
| Vehicle | 32 | 100% | 90.6% | 2.7 | 90.6% | 96.9% |
| Perampanel (0.1 mg/kg) | 8 | 100% | 87.5% | 2.6 | 87.5% | 100% |
| Perampanel (0.25 mg/kg) | 8 | 100% | 75% | 2.3 | 37.5% | 50% |
| Perampanel (0.65 mg/kg) | 8 | 100% | 37.5% | 1.1 | 12.5% | 12.5% |
| Perampanel (1 mg/kg) | 8 | 87.5% | 25% | 0.8 | 25% | 25% |
| Perampanel (2 mg/kg) | 8 | 87.5% | 0% | 0 | 0% | 0% |
| Diazepam (0.0625 mg/kg) | 8 | 100% | 100% | 3.0 | 75% | 100% |
| Diazepam (0.125 mg/kg) | 8 | 100% | 87.5% | 2.6 | 87.5% | 87.5% |
| Diazepam (0.25 mg/kg) | 22 | 95.5% | 45.5% | 1.4 | 36.4% | 59.1% |
| Diazepam (0.5 mg/kg) | 17 | 100% | 0% | 0 | 0% | 29.4% |
| Diazepam (1 mg/kg) | 8 | 62.5% | 0% | 0 | 0% | 12.5% |