Table 4.
Effects of post-treatment with perampanel and diazepam i.p. 5 min after oral administration of TETS (0.4 mg/kg) on the incidence of clonic and tonic seizures, tonic seizure severity, and the incidence of lethality at 1 h and 24 h
| Treatment (dose) | N | Clonic Seizures after treatment | Tonic seizures | Mean tonic seizure severity | Dead 1 h | Dead or unsalvageable 24 h |
|---|---|---|---|---|---|---|
| Vehicle | 15 | 100% | 100% | 3.0 | 100% | 100% |
| Perampanel (2 mg/kg) | 16 | 100% | 75% | 2.0 | 43.8% | 100% |
| Perampanel (4 mg/kg) | 16 | 87.5% | 56% | 1.6 | 44% | 75% |
| Perampanel (6 mg/kg) | 24 | 95.8% | 41.7% | 1.1 | 33.3% | 58.3% |
| Perampanel (8 mg/kg) | 15 | 80% | 53% | 1.5 | 47% | 47% |
| Perampanel (10 mg/kg) | 7 | 85.7% | 57.1% | 1.6 | 42.9% | 85.7% |
| Diazepam (1 mg/kg) | 7 | 85.7% | 71% | 2.1 | 71.4% | 71.4% |
| Diazepam (2 mg/kg) | 15 | 93.3% | 80% | 2.4 | 66.7% | 66.7% |
| Diazepam (2.5 mg/kg) | 8 | 75% | 12.5% | 0.38 | 12.5% | 12.5% |
| Diazepam (3 mg/kg) | 8 | 75% | 12.5% | 0.38 | 0% | 12.5% |
| Diazepam (4 mg/kg) | 7 | 14.3% | 14.3% | 0.43 | 14.3% | 14.3% |