Table 5.

Summary of ED₅₀ values for activity in MES test, motor impairment test, and for protection against TETS-induced tonic seizures and lethality

Test	ED50 ± SEM, mg/kg [95% CI]
		Perampanel	Diazepam
MES		1.50 ± 0.14 [1.22–1.78]
Horizontal Screen		1.19 ± 0.15 [0.89–1.48]
TETS (0.2 mg/kg, i.p.), pre-treatment	Tonic seizures	2.19 ± 0.19 [1.81–2.56]	2.15 ± 0.19 [1.79–2.51]
	Lethality at 1 h	1.63 ± 0.18 [1.27–1.98]	2.12 ± 0.23 [1.68–2.57]
TETS (0.14 mg/kg, i.p.), post-treatment (15 min)	Tonic seizures	0.44 ± 0.08 [0.28–0.60]	0.21 ± 0.03 [0.15–0.27]
	Lethality at 24 h	0.34 ± 0.08 [0.19–0.49]	0.32 ± 0.05 [0.23–0.42]
TETS (0.2 mg/kg, i.p.), post-treatment (5 min)	Tonic seizures	3.21 ± 0.33 [2.57–3.84]	0.86 ± 0.10 [0.67–1.06]
	Lethality at 1 h	2.18 ± 0.30 [1.60–2.76]	0.78 ± 0.13 [0.54–1.03]
TETS (0.4 mg/kg, p.o.), post-treatment (5 min)	Tonic seizures	Maximum protection: 6–8	2.02 ± 0.26 [1.51–2.54]
	Lethality at 24 h		1.85 ± 0.27 [1.33–2.37]