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. 2021 Jun 1;17(9):2262–2277. doi: 10.7150/ijbs.60131

Figure 2.

Figure 2

Mechanism of m6A. The dynamic modification of m6A modification is installed by the methylransferase complex (writers) composed of METTL3, METTL14, WTAP, KIA1429, ZC3H13 and RBM15/RBM15b, and removed by RNA demethylases (erasers) FTO and ALKBH5. Methyl-specific binding proteins (readers) in are the YTH family, which can achieve the biological functions of m6A modification.