Table 1.
The mechanism of m6A-modified circRNAs in pathological processes
| Type of disease | circRNA | Mechanisms of action | Putative biological function | Refs |
|---|---|---|---|---|
| Gastric cancer (GC) | circPVRL3 | miRNA sponge or template for translation | Proliferation and migration of GC cells |
129 |
| Poorly differentiated gastric adenocarcinoma (PDGA) | A set of circRNA (has-circRNA-0077837) | - | Progression of PDGA | 130 |
| Colorectal cancer (CC) | circNSUN2 | Protein scaffold (forms a circNUSN2/ IGF2BP2/ HMGA2 RNA-protein ternary complex) | Liver metastasis of CC | 128 |
| Hepatocellular carcinoma (HCC) | circRNA-SORE | miRNA sponge (miR-103a-2-5p and miR-660-3p) | Sorafenib resistance of HCC | 132 |
| Esophageal squamous cell carcinoma | circSLC7A5 | Template for translation | Biomarker for cancer diagnosis and prognosis | 140 |
| Cervical carcinoma | circE7 | Template for translation (E7 oncoprotein) | Link to the transforming properties of some human papillomaviruses | 143 |
| Acute coronary syndrome | Has_circ_029589 | - | Induce macrophage pyrptosis | 146 |
| Hypoxia mediated pulmonary hypertension | A set of circRNAs (circ-Xpo6, circ-Tmtc3 ) | Affect the circRNA-miRNA-mRNA network | Potential therapy targets | 147 |
| Major sepressive disorder | circSTAG1 | Protein partner (Binding with ALKBH5) | Depressive | 135 |