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. 2021 Jun 1;17(9):2252–2261. doi: 10.7150/ijbs.61073

Table 1.

Comparison of three HO isozymes

HO-1 HO-2 HO-3
Molecular weight
Inducibility
Activity level
32kD
Stress-inducible
High
36kD
Constitutive
High
Unknown
Unknown
Low
Highly-Expressed localization Live, spleen, bone marrow, senescent erythrocytes Brain, retina and testis Widely distributed
Similarity Degrade heme into biliverdin, carbon monoxide, ferrous ion and bilirubin