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. 2021 Jun 11;17(9):2348–2355. doi: 10.7150/ijbs.57810

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Effects of capivasertib on VSV-dG-Luc in Vero cells with SARS-CoV-2 spike overexpression or not. A. and B. Control vector pCAGGS (A) and the recombinant vector pCAGGS-HA-spike (B) were transfected into Vero cells for 24 h, respectively. Then, cells infected by VSV-dG-Luc at an MOI of 1 were incubated with different concentrations of capivasertib (0, 0.1 μM, 1 μM, and 10 μM), respectively. After 20 h, cells were collected and intracellular luciferase activity was analyzed by luciferase reporter assay.