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. 2021 Jun 11;17(9):2348–2355. doi: 10.7150/ijbs.57810

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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An intracellular pathway model for pharmacological blockage of PI3K(PIK3CA)/AKT signal axis restricting the entry of viruses including SARS-CoV-2. activation or promotion; inactivation or inhibition; PI3K, phosphatidylinositol 3-kinase; PIK3CA, phosphatidylinositol 3-kinase catalytic subunit α; AKT, serine/threonine kinase (PKB, protein kinase B); PIKFYVE, FYVE finger-containing phosphoinositide kinase; PtdIns3P, phosphatidylinositol-3-phosphate; PtdIns(3,5)P2, phosphatidylinositol-3,5-biphosphate.

Inline graphic — An intracellular pathway model for pharmacological blockage of PI3K(PIK3CA)/AKT signal axis restricting the entry of viruses including SARS-CoV-2. activation or promotion; inactivation or inhibition; PI3K, phosphatidylinositol 3-kinase; PIK3CA, phosphatidylinositol 3-kinase catalytic subunit α; AKT, serine/threonine kinase (PKB, protein kinase B); PIKFYVE, FYVE finger-containing phosphoinositide kinase; PtdIns3P, phosphatidylinositol-3-phosphate; PtdIns(3,5)P2, phosphatidylinositol-3,5-biphosphate.