KEGG pathway analyses showed that these up-regulated genes participated in pathway: cytokine-cytokine receptor interaction, amoebiasis, chemokine signaling pathway, neuroactive ligand-receptor interaction, rheumatoid arthritis, pathways in cancer, transcriptional misregulation in cancer, serotonergic synapse, TNF signaling pathway, chemical carcinogenesis et al. For the down-regulated genes of pathway analysis: chemical carcinogenesis, drug metabolism-cytochrome P450, metabolism of xenobiotics by cytochrome P450, retinol metabolism, tyrosine metabolism and neuroactive ligand-receptor interaction et al.