Table 4.
The process of identified six miRNAs that may be involved in regulating the hub-genes (A-D).
| Hub-genes (15 up-regulate) | A: the possible miRNAs in ENCORI database (number) | B: miRNA were down-regulated in TCGA (33) | C: Take the intersection of A and B jointly owned | D: correlation analysis of hub-genes and C | |
|---|---|---|---|---|---|
| CXCL1 | 83 | hsa-mir-653 hsa-mir-1258 hsa-mir-466 hsa-mir-1247 hsa-mir-362 hsa-mir-4501 hsa-mir-489 hsa-mir-194-1 hsa-mir-605 hsa-mir-513a-2 hsa-mir-513a-1 hsa-mir-194-2 hsa-mir-873 hsa-mir-4423 hsa-mir-6842 hsa-mir-876 hsa-mir-585 |
hsa-mir-99a hsa-mir-6788 hsa-mir-150 hsa-mir-514a-3 hsa-mir-514a-1 hsa-mir-514a-2 hsa-mir-125b-2 hsa-mir-510 hsa-mir-125b-1 hsa-mir-507 hsa-mir-592 hsa-mir-513b hsa-mir-6757 hsa-mir-552 hsa-mir-1287 hsa-mir-508 |
hsa-mir-873 hsa-mir-489 hsa-mir-362 hsa-mir-513b hsa-mir-653 | hsa-mir-513b |
| CXCL3 | 101 | hsa-mir-873 hsa-mir-489 hsa-mir-362 hsa-mir-150 hsa-mir-653 | NO | ||
| CXCL5 | 100 | hsa-mir-876 hsa-mir-873 hsa-mir-513b | NO | ||
| CXCL6 | 77 | hsa-mir-873 hsa-mir-362 | NO | ||
| CXCL8 | 155 | hsa-mir-876 hsa-mir-873 hsa-mir-362 hsa-mir-508 hsa-mir-513b hsa-mir-653 | hsa-mir-873 hsa-mir-508 hsa-mir-513b | ||
| CXCL11 | 8 | 0 | NO | ||
| CXCR1 | 1 | hsa-mir-873 | NO | ||
| DRD2 | 0 | 0 | NO | ||
| FPR2 | 16 | hsa-mir-362 | NO | ||
| GNGT1 | 2 | 0 | NO | ||
| GNAT3 | 0 | 0 | NO | ||
| HCAR2 | 0 | 0 | NO | ||
| HTR1D | 0 | 0 | NO | ||
| OPRD1 | 0 | 0 | NO | ||
| PPY | 119 | hsa-mir-873 hsa-mir-489 | hsa-mir-873 hsa-mir-489 | ||
| Hub-genes (7 down-regulate) | A: the possible miRNAs in ENCORI database (number) | B: miRNA were down-regulated in TCGA (47) | C: Take the intersection of A and B jointly owned | D: correlation analysis of hub-genes and C | |
| C3 | 22 | hsa-mir-31 hsa-mir-135b hsa-mir-190b hsa-mir-582 hsa-mir-4465 hsa-mir-372 hsa-mir-214 hsa-mir-223 hsa-mir-130b hsa-mir-548az hsa-mir-7114 hsa-mir-4668 hsa-mir-301b hsa-mir-141 hsa-mir-6720 hsa-mir-3170 hsa-mir-215 hsa-mir-887 hsa-mir-330 hsa-mir-301a hsa-mir-18a hsa-mir-1245a hsa-mir-146b hsa-mir-199b |
hsa-mir-222 hsa-mir-205 hsa-mir-4746 hsa-mir-221 hsa-mir-3917 hsa-mir-6783 hsa-mir-6772 hsa-mir-4515 hsa-mir-199a-1 hsa-mir-199a-2 hsa-mir-92b hsa-mir-3662 hsa-mir-675 hsa-mir-937 hsa-mir-499a hsa-mir-1226 hsa-mir-124-2 hsa-mir-7106 hsa-mir-549a hsa-mir-3622a hsa-mir-1269b hsa-mir-371a hsa-mir-124-1 |
0 | NO |
| CX3CR1 | 0 | 0 | NO | ||
| GRM8 | 4 | 0 | NO | ||
| HTR1B | 0 | 0 | NO | ||
| PTGER3 | 132 | hsa-mir-371a hsa-mir-214 hsa-mir-675 hsa-mir-4465 hsa-mir-372 hsa-mir-499a hsa-mir-199b | hsa-mir-4465 | ||
| SUCNR1 | 0 | 0 | NO | ||
| SSTR1 | 118 | hsa-mir-371a hsa-mir-330 hsa-mir-146b hsa-mir-582 hsa-mir-214 hsa-mir-499a | hsa-mir-330 | ||