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. 2021 May 29;95(7):2413–2430. doi: 10.1007/s00204-021-03075-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Cell viability (LDH) in response to pharmaceutical compounds. a LDH cell viability in response to APAP (0,0.1,10,10 mM) over 24 and 48 h (n = 3). b LDH cell viability in response to midazolam (0, 1, 10, 100, and 1000 µM) over 24 and 48 h (n = 3). c LDH cell viability in response to irinotecan (0, 1, 10, and 100 µM) over 24 and 48 h (n = 3). All doses/time points were replicated in both differentiated and undifferentiated states. One-Way ANOVA was performed on differentiated vs undifferentiated on parallel dose/time points. Ns = not significant, * = 0.1, ** = 0.05, *** = 0.01. 24 h undifferentiated, 24 h differentiated, 48 h undifferentiated, 48 h differentiated (color figure online)

Inline graphic — Cell viability (LDH) in response to pharmaceutical compounds. a LDH cell viability in response to APAP (0,0.1,10,10 mM) over 24 and 48 h (n = 3). b LDH cell viability in response to midazolam (0, 1, 10, 100, and 1000 µM) over 24 and 48 h (n = 3). c LDH cell viability in response to irinotecan (0, 1, 10, and 100 µM) over 24 and 48 h (n = 3). All doses/time points were replicated in both differentiated and undifferentiated states. One-Way ANOVA was performed on differentiated vs undifferentiated on parallel dose/time points. Ns = not significant, * = 0.1, ** = 0.05, *** = 0.01. 24 h undifferentiated, 24 h differentiated, 48 h undifferentiated, 48 h differentiated (color figure online)