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. 2021 Jun 29;12:4012. doi: 10.1038/s41467-021-24184-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In the first step, a long-range electrostatic search via the mobile and charged X1 region attracts the LG domain of laminin to integrin (the first panel). The II-III loop fixes the relative orientation between the integrin and laminin (the second panel). The flexible γ1-tail is fixed via two anchor points (i.e., LMγ1 P1609-α6 N189 and LMγ1 E1607-MIDAS), which induces local conformational rearrangement of α1 and α7 helices in the integrin βI domain, making the hybrid domain swing out (the third panel). Eventually, α6β1 is converted into the extended-open conformation (the last panel).