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. 2021 Jun 29;4:810. doi: 10.1038/s42003-021-02306-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Melting profiles for 16 protein with posterior probability >0.99 in favour of a condition-dependent model using the Bayesian sigmoid model. Points are observed protein measurements. The inferred mean function from the sigmoid model is plotted as a line and the 95% credible band is given by the shaded region. Purple denotes the drug treated context, whilst yellow denotes the control. Statistics derived from two biological replicates, for each of two conditions each with 10 measure temperatures.