Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 29;11:13454. doi: 10.1038/s41598-021-92966-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fenofibrate upregulates expression of tight junctions on intestinal epithelial cells. Immunofluorescent staining of claudin-1 (CLD-1) expression in the (a) duodenum, (b) ileum, and (c) colon of diabetic dogs pre- and post-fenofibrate administration. (d–f) Semi-quantitation of CLD-1 protein expression in the intestinal compartments. (g) Representative ZO-1 staining and (h) quantification of barrier tortuosity in Caco-2 cells treated with different concentrations of glucose + 10 μM fenofibrate + 3 μM GW6741 or (i, j) TNF-α + fenofibrate + GW6741 for 24 h. *P < 0.05, **P < 0.01, ***P < 0.001 by (a–f) mixed models ANOVA and (g–j) one-way ANOVA with Tukey’s multiple comparison test. N.S., not significant.