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. 2021 Jun 29;11:13454. doi: 10.1038/s41598-021-92966-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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No changes in the fecal microbiota were associated with fenofibrate treatment in diabetic dogs. (a) Frequencies of amplicon sequence variants (ASVs) in fecal samples collected pre- and post-fenofibrate treatment. (b) Evaluation of alpha diversity using Observed, Chao1, ACE, Shannon, and Simpson indices. (c) Bar chart showing relative abundance of bacterial phyla among samples collected before and after fenofibrate administration in each of 7 dogs (A-G) with experimentally-induced DM. (d) Weighted UniFrac PCoA analysis of microbiota composition in identical animals pre- and post-fenofibrate treatment. Circles represent regions of 95% confidence. (e) Volcano plot representing differentially abundant bacterial phyla where P < 0.05. Numbers of differentially abundant bacterial (f) phyla, (g) class, (h) order, and (i) family between pre- and post-fenofibrate samples DESeq2 with phyloseq and omu on R software.