Table 1.
Unique amino acid signature of cosmopolitan genotype.
| Polyprotein position | Gene | Gene position | REF | Other genotypes | Cosmopolitan genotype (% of fixationa) |
|---|---|---|---|---|---|
| 166 | preM/M | 52 | K | K | N (100%) |
| 196 | preM/M | 82 | T | T | A (99%) |
| 262 | preM/M | 148 | H | H | Y (96%) |
| 351 | E | 71 | E/D | E/D | A (100%) |
| 429 | E | 149 | H | H | N (99%) |
| 670 | E | 390 | N/D | N/D | S (97%) |
| 742 | E | 462 | I | I | V (99%) |
| 1635 | NS3 | 160 | A/S | A/S | T (100%) |
| 2256 | NS4B | 13 | L | L | F (99%) |
| 2496 | NS5 | 5 | I/V/M | I/V/M | T (99%) |
| 2506 | NS5 | 15 | S | S | N (100%) |
| 2826 | NS5 | 335 | V/L | V/L | I (100%) |
aThe percentage values indicate the extent of fixation of each mutation in 445 sequences of cosmopolitan genotype as compared to 1,007 sequences of other genotypes of DENV-2. NCBI reference sequence NC_001474.2 was used as the reference (REF) genome. M membrane, NS non-structural proteins, preM pre-membrane.