TABLE 5.

AUC/MIC simulation of TGC in different range of BUN.

Maintenance dose	BUN (mmol/l)	fAUC0–24 h/MIC50 (h)	fAUC0–24 h/MIC90 (h)
50 mg	4.7 (1.8–7.5)	0.8	0.4
50 mg	8.3 (7.5–9)	0.95	0.45
50 mg	14.5 (9–20)	1.1	0.55
50 mg	34.2 (20–48.3)	1.4	0.7
100 mg	4.7 (1.8–7.5)	1.6	0.8
100 mg	8.3 (7.25–9)	1.9	0.95
100 mg	14.5 (9–20)	2.2	1.1
100 mg	34.2 (20–48.3)	2.75	1.4

AUC, area under curve; MIC, minimum inhibitory concentration; TGC, tigecycline; BUN, blood urea nitrogen. According to the ranges of BUN, the renal function is classified into four grades. Normal, BUN 1.8–7.5 mmol/l; renal insufficiency (compensatory stage), BUN ≤ 9 mmol/L; renal insufficiency (incompensatory stage), BUN > 9 mmol/l; renal failure, >20 mmol/l.