Table 3.
The C-index of HBV-related ACLF-Nomogram and different scoring systems for prediction of 90 days' survival in the derivation and validation cohorts.
| Derivation cohort | Validation cohort | |||
|---|---|---|---|---|
| Factor | C-index (95%CI) | P-value† | C-index (95%CI) | P-value† |
| HBV-ACLF-Nomogram | 0.790 (0.773,0.807) |
0.793 (0.770,0.817) |
||
| MELD | 0.717 (0.697,0.736) |
0.712 (0.682,0.741) |
||
| MELD-Na | 0.709 (0.689,0.728) |
0.715 (0.686,0.744) |
||
| CTP | 0.627 (0.606,0.647) |
0.629 (0.598,0.659) |
||
| CLIF-C OF | 0.727 (0.701,0.754) |
|||
| CLIF-C ACLF | 0.746 (0.720,0.772) |
|||
| COSSH ACLF | 0.762 (0.737,0.787) |
|||
| HBV-ACLF-Nomogram vs. MELD | <0.001 | <0.001 | ||
| HBV-ACLF-Nomogram vs. MELD-Na | <0.001 | <0.001 | ||
| HBV-ACLF-Nomogram vs. CTP | <0.001 | <0.001 | ||
| HBV-ACLF-Nomogram vs. CLIF-C OF | <0.001 | |||
| HBV-ACLF-Nomogram vs. CLIF-C ACLF | 0.001 | |||
| HBV-ACLF-Nomogram vs. COSSH ACLF | 0.002 | |||
C-index, concordance index; HBV, hepatitis B virus; ACLF, acute on chronic liver failure; CI, confidence interval; MELD, model for end-stage liver disease; MELD-Na, model for end-stage liver disease with the addition of the Na level; CTP, child-Turcotte-Pugh; CLIF-C OF, CLIF-consortium organ failure score; CLIF-C ACLF, CLIF-consortium acute-on-chronic liver failure score; COSSH ACLF, Chinese group on the study of severe hepatitis B acute-on-chronic liver failure score.
†
P-values are calculated based on normal approximation using function rcorrp.cens in Hmisc package.