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. 2021 Jun 29;11:13484. doi: 10.1038/s41598-021-92871-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TGF-β1 activated YAP/TAZ in HVOX. HVOX fibroblasts were treated with or without 10 ng/mL TGF-β1 for 24 h. Expression of ACTA2 (a), target genes of YAP/TAZ (b, CCN2; c CYR61; d EDN1; e FSTL1; f INHBA), YAP1 (g), and WWTR1 (h) were analyzed by qPCR (Data shown as mean ± SD; n = 3; *p < 0.05, Student’s t-test). YAP/TAZ nuclear localization was examined by immunostaining (i; bar = 50 µm).